Description

Ethyl 5-Cyano-6-Methyl-2-(Trifluoromethyl)Nicotinate is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with cyano, methyl, and trifluoromethyl groups. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules with tailored properties. It is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical building block for developing new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, enabling more efficient and selective chemical transformations.
• Chemical Biology Probe: Utilized as a core structure for designing molecular probes and inhibitors to study enzyme function and biological pathways.

Basic Information

Product Name	Ethyl 5-Cyano-6-Methyl-2-(Trifluoromethyl)Nicotinate
CAS No.	445-71-6
Molecular Formula	C11H9F3N2O2
Molecular Weight	258.20 g/mol
Synonyms	Ethyl 5-cyano-6-methyl-2-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-cyano-6-methyl-2-(trifluoromethyl)-, ethyl ester; 5-Cyano-6-methyl-2-(trifluoromethyl)nicotinic acid ethyl ester; 2-(Trifluoromethyl)-5-cyano-6-methylnicotinic acid ethyl ester; Ethyl 2-trifluoromethyl-5-cyano-6-methylnicotinate; 445-71-6; 5-Cyano-6-methyl-2-trifluoromethylnicotinic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Cyano-6-Methyl-2-(Trifluoromethyl)Nicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, NMR, and GC-MS analyses. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.