Description

Estrone 3-Sulfate Sodium Salt is a high-purity, water-soluble conjugated estrogen derivative, essential for research and development in endocrinology. This compound serves as a critical reference standard and precursor for studying estrogen metabolism, hormone replacement therapies, and steroid biochemistry. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis and quality control of estrogen-based pharmaceuticals.
• Biochemical Research: A key substrate for studying the activity of steroid sulfatase and sulfotransferase enzymes involved in hormone regulation.
• Diagnostic Reagent Manufacturing: Employed in the production of calibration standards and controls for clinical diagnostic kits measuring estrogen levels.
• API Synthesis: Acts as a strategic intermediate in the synthesis of more complex steroid hormones and their conjugates.
• Cell Culture & In Vitro Studies: Used in research models to investigate estrogen receptor signaling and the effects of estrogen sulfates in various tissues.

Basic Information

Product Name	Estrone 3-Sulfate Sodium Salt
CAS No.	438-67-5
Molecular Formula	C18H21NaO5S
Molecular Weight	372.41 g/mol
Synonyms	Estrone Sulfate Sodium Salt; Sodium Estrone Sulfate; E1S Sodium Salt; Estrone 3-(Sodium Sulfate); 3-Sulfooxyestra-1,3,5(10)-trien-17-one Sodium Salt; NSC 14769; Estrone-3-O-sulfate Sodium Salt; Estrone Sodium Sulfate
EINECS	207-119-7

Quality Control

Our Estrone 3-Sulfate Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production requirements. Specifications can meet the needs of various application grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.