Description

2,2,2-Trifluoroethyl p-Toluenesulfonate is a versatile organofluorine building block and alkylating agent. This compound is valued for its ability to introduce the 2,2,2-trifluoroethoxy group into target molecules, significantly altering their physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs) containing trifluoroethyl ether or ester moieties, often to enhance metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used to create fluorinated analogs of herbicides, fungicides, and insecticides, where fluorine incorporation can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated components for electronic displays and organic light-emitting diodes, improving dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: Acts as an electrophile in transition-metal catalyzed reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds with fluorinated segments.
• Protecting Group Chemistry: Can be used to install a base-labile protecting group for alcohols and carboxylic acids in complex multi-step syntheses.

Basic Information

Product Name	2,2,2-Trifluoroethyl p-Toluenesulfonate
CAS No.	433-06-7
Molecular Formula	C9H9F3O3S
Molecular Weight	254.23 g/mol
Synonyms	2,2,2-Trifluoroethyl Tosylate; 2,2,2-Trifluoroethyl 4-Methylbenzenesulfonate; p-Toluenesulfonic Acid 2,2,2-Trifluoroethyl Ester; Trifluoroethyl Tosylate; α,α,α-Trifluoroethyl p-Toluenesulfonate; 4-Methylbenzenesulfonic Acid 2,2,2-Trifluoroethyl Ester; Tosyloxytrifluoroethane
EINECS	207-089-7

Quality Control

Our 2,2,2-Trifluoroethyl p-Toluenesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.