Description

2-Chloro-1,1-Difluoro-1-Methoxyethane is a versatile halogenated ether building block with significant utility in advanced chemical synthesis. This compound matters for its role as a key intermediate in the production of pharmaceuticals, agrochemicals, and specialty materials, where its unique difluoromethoxy and chloroethane structure enables precise molecular modifications. It is needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fluorochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the introduction of the difluoromethoxy group into drug candidates, particularly in medicinal chemistry for metabolic stability enhancement.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where fluorine incorporation improves biological activity and environmental persistence.
• Fluorochemical Production: Serves as a precursor for specialty surfactants, refrigerants, and fluorinated polymers.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to construct complex organic molecules in research and development.
• Material Science: Potential use in the synthesis of monomers for specialty coatings and electronic materials requiring specific dielectric properties.

Basic Information

Product Name	2-Chloro-1,1-Difluoro-1-Methoxyethane
CAS No.	428-65-9
Molecular Formula	C3H5ClF2O
Molecular Weight	130.52 g/mol
Synonyms	Chlorodifluoromethoxyethane; 1-Chloro-2,2-difluoro-1-methoxyethane; Methane, chlorofluoromethoxyfluoro-; Difluorochloromethoxyethane; 2-Chloro-1,1-difluoroethyl methyl ether; Methyl 2-chloro-1,1-difluoroethyl ether; EINECS 207-060-8
EINECS	207-060-8

Quality Control

Our 2-Chloro-1,1-Difluoro-1-Methoxyethane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, keep containers tightly sealed and handle in a fume hood. Recommended storage temperature is between 2°C and 8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.