Description

3'-Hydroxyhexobarbital is a key pharmaceutical intermediate and reference standard, primarily known for its role in metabolism studies and analytical applications. This compound is critical for ensuring the quality, safety, and efficacy of related pharmaceutical products through precise analytical control. It is essential for research and development laboratories, quality control departments, and manufacturers in the pharmaceutical and life sciences sectors requiring high-purity chemical standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments and validation of testing methods in pharmacopeial compliance.
• Metabolite Analysis: Serves as a critical metabolite standard in pharmacokinetic and drug metabolism studies for related barbiturate compounds.
• Quality Control (QC) Testing: Employed in pharmaceutical QC laboratories for the identification and quantification of impurities or related substances in active pharmaceutical ingredients (APIs) and finished drug products.
• Forensic and Clinical Toxicology: Utilized as an analytical standard in forensic labs and clinical settings for the accurate detection and measurement of specific barbiturates and their metabolites in biological samples.
• Research and Development: Acts as a building block or intermediate in the synthetic pathway for developing new chemical entities or for metabolic pathway investigation in academic and industrial R&D.
• Method Development and Validation: Essential for developing, optimizing, and validating chromatographic (HPLC, GC) and spectroscopic analytical methods.

Basic Information

Product Name	3'-Hydroxyhexobarbital
CAS No.	427-29-2
Molecular Formula	C12H16N2O4
Molecular Weight	252.27 g/mol
Synonyms	3'-Hydroxyhexobarbital; 5-(1-Cyclohexen-1-yl)-1,5-dimethylbarbituric acid 3'-hydroxy derivative; 1,5-Dimethyl-5-(1-cyclohexen-1-yl)barbituric acid 3'-ol; Hexobarbital 3'-hydroxy metabolite; 3'-OH-Hexobarbital; 3-Hydroxyhexobarbital; 3'-Hydroxy-1,5-dimethyl-5-cyclohexenylbarbituric acid
EINECS	Contact for details

Quality Control

Our 3'-Hydroxyhexobarbital is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for use as a reference material. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.