Description

21-Acetyloxy-17-Hydroxy-16-Methylpregn-4-Ene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical manufacturing. Its core value lies in its role as a key precursor for the synthesis of potent corticosteroid and progestogen APIs, enabling the production of critical therapeutic agents. This compound is essential for R&D laboratories and production facilities specializing in steroid-based pharmaceuticals, including anti-inflammatory, immunosuppressive, and hormonal treatments.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced corticosteroid drugs such as dexamethasone and betamethasone derivatives.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key precursor in multi-step synthesis pathways for high-potency glucocorticoids.
• Research & Development: Utilized in medicinal chemistry for the development and optimization of new steroidal compounds with targeted biological activity.
• Process Chemistry & Scale-Up: Employed in pilot plants and commercial manufacturing for process validation and production of steroid-based therapeutics.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid products.

Basic Information

Item	Details
Product Name	21-Acetyloxy-17-Hydroxy-16-Methylpregn-4-Ene-3,20-Dione
CAS No.	426-43-7
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.51 g/mol
Synonyms	16β-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate; 21-Acetoxy-11β,17α-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 16β-Methylprednisolone 21-acetate; Prednisolone 21-acetate, 16β-methyl-; U-8471; NSC-47439; 11β,17α,21-Trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 21-Acetyloxy-17-Hydroxy-16-Methylpregn-4-Ene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and related substances, identity confirmation by IR and NMR, and residual solvent analysis to ensure compliance with ICH guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.