Description

2-Fluoroisonicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic introduction of both a fluorine atom and a carboxylic acid group onto the pyridine ring, enabling precise modulation of molecular properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine-tuning the pharmacokinetics of lead compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and markers for biochemical and diagnostic applications.

Basic Information

Product Name	2-Fluoroisonicotinic Acid
CAS No.	402-65-3
Molecular Formula	C6H4FNO2
Molecular Weight	141.10 g/mol
Synonyms	2-Fluoropyridine-4-carboxylic Acid; 4-Carboxy-2-fluoropyridine; Isonicotinic Acid, 2-Fluoro-; 2-Fluoro-4-pyridinecarboxylic Acid; 2-Fluoropyridine-4-carboxylic Acid; 2-Fluoro-4-carboxypyridine; 402-65-3; 2-Fluoropyridine-4-carboxylic acid (ACD/Name 4.0)
EINECS	Contact for details

Quality Control

Our 2-Fluoroisonicotinic Acid is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its acidic nature, handle with appropriate personal protective equipment in a fume hood or well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	205 - 210 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.