Description

Trimethylsilyl Trifluoroacetate is a versatile organosilicon reagent primarily used as a powerful silylating agent and derivatization compound. Its core value lies in its ability to introduce the trimethylsilyl (TMS) group into target molecules, enhancing their volatility and stability for analytical techniques like gas chromatography. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise chemical synthesis and analysis.

Application

• Derivatization Agent for GC/MS Analysis: Used to silylate polar functional groups (e.g., -OH, -COOH) in complex mixtures like metabolites, steroids, and organic acids to improve their chromatographic detection and separation.
• Pharmaceutical Intermediate: Serves as a key reagent in the synthesis and protection of sensitive intermediates during the production of active pharmaceutical ingredients (APIs).
• Polymer and Material Science: Employed in surface modification and the synthesis of specialty silicones and fluorinated polymers to impart specific chemical properties.
• Protecting Group Chemistry: Effectively protects carboxylic acid and alcohol groups in multi-step organic synthesis, facilitating selective reactions.
• Agrochemical Synthesis: Utilized in the manufacturing process of certain advanced pesticides and herbicides where fluorinated and silylated structures are required.
• NMR Spectroscopy: Can be used as a shift reagent or for sample preparation to aid in the structural elucidation of complex organic molecules.

Basic Information

Product Name	Trimethylsilyl Trifluoroacetate
CAS No.	400-53-3
Molecular Formula	C5H9F3O2Si
Molecular Weight	186.20 g/mol
Synonyms	Trifluoroacetic Acid Trimethylsilyl Ester; Trimethylsilyl Trifluoroacetate; TMS-Trifluoroacetate; (Trimethylsilyl) 2,2,2-Trifluoroacetate; Trimethylsilyl Ester of Trifluoroacetic Acid; TMS-TFA; Silicon, Trimethyl(2,2,2-trifluoroacetato-O)-; Acetic Acid, 2,2,2-Trifluoro-, Trimethylsilyl Ester
EINECS	206-915-0

Quality Control

Our Trimethylsilyl Trifluoroacetate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.