Description

Isopropyl Trifluoroacetate is a versatile fluorinated ester compound valued for its high reactivity and volatility. It serves as a critical reagent and building block in advanced organic synthesis, particularly for introducing the trifluoroacetyl protecting group. This chemical is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical industries seeking efficient fluorination and derivatization pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring trifluoroacetyl protection of amines or alcohols.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity.
• Peptide Chemistry: Acts as a reagent for N-terminal blocking in peptide synthesis to prevent unwanted side reactions.
• Analytical Derivatization Agent: Employed in gas chromatography (GC) and mass spectrometry (MS) to volatilize and analyze compounds containing amine or hydroxyl groups.
• Specialty Polymer Production: A monomer or modifier in the synthesis of fluorinated polymers with unique chemical resistance and surface properties.
• Organic Synthesis Reagent: Utilized in various reactions, including esterifications and acylations, where its high volatility can aid in reaction work-up and purification.

Basic Information

Product Name	Isopropyl Trifluoroacetate
CAS No.	400-38-4
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	2-Propanol, 1,1,1-trifluoroacetate; 2-Propyl trifluoroacetate; Trifluoroacetic acid isopropyl ester; Isopropyl trifluoroethanoate; TFAA isopropyl ester; IPA-TFA; 1-Methylethyl trifluoroacetate
EINECS	206-911-6

Quality Control

Our Isopropyl Trifluoroacetate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of industrial and research applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and maintain product integrity. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.320 - 1.340
Density (20°C)	1.15 - 1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.