Description

Isopropyl Trifluoroacetate is a versatile fluorinated ester compound, valued for its role as a powerful acylating and trifluoroacetylating agent in advanced organic synthesis. Its high volatility and reactivity make it a critical reagent for introducing the trifluoroacetyl group, a key moiety in pharmaceuticals and agrochemicals. This product is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking efficient fluorination and protection strategies.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of trifluoroacetyl-protected amines and amino acids in active pharmaceutical ingredient (API) manufacturing.
• Agrochemical Production: Used in the synthesis of fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and stability.
• Peptide Chemistry: Serves as a protecting group for amino functions during solid-phase and solution-phase peptide synthesis.
• Analytical Derivatization: Employed to derivative compounds for gas chromatography (GC) or mass spectrometry (MS) analysis to improve volatility and detection.
• Organic Synthesis Reagent: Acts as a solvent and acylating agent in various organic transformations, including esterifications and Friedel-Crafts reactions.
• Material Science: Potential precursor in the synthesis of fluorinated polymers and coatings with unique surface properties.

Basic Information

Product Name	Isopropyl Trifluoroacetate
CAS No.	400-37-3
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	2-Propanol, 1,1,1-trifluoroacetate; 2-Propyl trifluoroacetate; Trifluoroacetic acid isopropyl ester; Isopropyl ester of trifluoroacetic acid; IPA-TFA; TFAA-IPA; 1-Methylethyl trifluoroacetate
EINECS	206-915-1

Quality Control

Our Isopropyl Trifluoroacetate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for critical industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases, oxidizing agents, and amines. Recommended storage temperature is 2-8°C to maintain optimal stability and minimize volatility. Keep container tightly sealed when not in use to prevent moisture absorption and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.320 - 1.340
Density (20°C)	1.18 - 1.22 g/mL
Related Substances (GC)	Individual ≤ 0.5%, Total ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.