Description

tert-Butyl 3-Amino-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is a high-purity, protected heterocyclic amine building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical synthetic intermediate, enabling the construction of complex molecular scaffolds with potential biological activity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Scaffold: Used to build and diversify libraries of compounds for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Kinase Inhibitor Development: The pyrazolopyridine core is a privileged structure in the design of protein kinase inhibitors.
• Peptidomimetic Research: Serves as a constrained, heterocyclic scaffold to mimic peptide secondary structures.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target validation.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 3-Amino-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
CAS No.	398491-64-0
Molecular Formula	C11H18N4O2
Molecular Weight	238.29 g/mol
Synonyms	5-(tert-Butoxycarbonyl)-3-amino-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine; 3-Amino-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylic acid tert-butyl ester; tert-Butyl 3-amino-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylate; 5-Boc-3-amino-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine; 3-Amino-5-Boc-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridine; 398491-64-0; tert-Butyl 3-amino-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.