Description

Ethyl 2-Amino-3-Cyclobutylpropanoate is a specialized chiral building block featuring a cyclobutane ring, a structure of significant interest in modern medicinal chemistry for its role in conformational restriction. This compound is valued for its utility in the synthesis of novel pharmacologically active molecules, particularly as a precursor for constrained amino acid analogs. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for constructing advanced intermediates in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Constrained Amino Acid Analog Synthesis: Serves as a crucial precursor for creating non-natural, cyclobutane-containing amino acids used to modulate peptide stability, bioavailability, and receptor selectivity.
• Agrochemical Research: Employed in the discovery of novel herbicides and pesticides, where the cyclobutyl moiety can impart unique biological activity and environmental stability.
• Ligand and Catalyst Development: Used in academic and industrial research to develop novel chiral ligands and organocatalysts for asymmetric synthesis.
• Peptidomimetics: Integral to the design and synthesis of peptidomimetic compounds that mimic natural peptides but with enhanced metabolic stability and membrane permeability.

Basic Information

Product Name	Ethyl 2-Amino-3-Cyclobutylpropanoate
CAS No.	394735-17-2
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	Ethyl 2-amino-3-cyclobutylpropanoate; 2-Amino-3-cyclobutylpropanoic acid ethyl ester; 3-Cyclobutyl-DL-alanine ethyl ester; Ethyl 3-cyclobutylalaninate; DL-2-Amino-3-cyclobutylpropionic acid ethyl ester; (RS)-2-Amino-3-cyclobutylpropanoic acid ethyl ester; Ethyl β-amino-β-cyclobutylpropionate; NSC 760463
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-3-Cyclobutylpropanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, enantiomeric excess (where applicable), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Specific Rotation (Optional)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.