Description

1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-4-Methylene-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds. It is essential for research and production teams in pharmaceutical R&D, agrochemical synthesis, and fine chemical manufacturing who require reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Research: Used to introduce constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing advanced, chiral active ingredients with specific biological activity.
• Asymmetric Catalysis Ligand Precursor: Utilized in the preparation of novel chiral ligands and organocatalysts for stereoselective transformations.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-4-Methylene-, 1,1-Dimethylethyl Ester
CAS No.	390381-86-9
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	tert-Butyl 3-hydroxy-4-methylenepyrrolidine-1-carboxylate; 1-Boc-3-hydroxy-4-methylenepyrrolidine; 3-Hydroxy-4-methylenepyrrolidine-1-carboxylic acid tert-butyl ester; (3-Hydroxy-4-methylenepyrrolidin-1-yl)-tert-butoxycarbonyl; N-Boc-3-hydroxy-4-methylenepyrrolidine; Boc-3-hydroxy-4-methylenepyrrolidine; 1-(tert-Butoxycarbonyl)-3-hydroxy-4-methylenepyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-4-Methylene-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.