Description

Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4R)- (9Ci) is a high-purity, stereochemically defined fluorinated building block of significant interest in advanced organic synthesis. Its unique dispirocyclic core and strategically placed fluorine atoms make it a valuable scaffold for constructing complex molecular architectures with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a sophisticated chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the fluorinated dispiro structure can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with unique thermal or optical properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create novel chiral ligands and catalysts for asymmetric synthesis.
• Chemical Biology Probe: Utilized as a molecular scaffold for designing chemical probes to study enzyme function and protein-ligand interactions.
• Academic & Industrial R&D: A key reagent for methodological studies in organic chemistry, exploring new fluorination and cyclization reactions.

Basic Information

Item	Details
Product Name	Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4R)- (9Ci)
CAS No.	389873-52-3
Molecular Formula	C8H10F2O
Molecular Weight	160.16 g/mol
Synonyms	(1S,3R,4R)-5,5-Difluorodispiro[2.0.2.1]heptane-1-methanol; (1S,3R,4R)-5,5-Difluoro-1-(hydroxymethyl)dispiro[2.0.2.1]heptane; 5,5-Difluorodispiro[2.0.2.1]heptane-1-methanol, (1S,3R,4R)-; Difluorinated Dispiroheptane Methanol Derivative; Chiral Fluorinated Bicyclic Alcohol; CAS 389873-52-3
EINECS	Contact for details

Quality Control

Every batch of Dispiro[2.0.2.1]Heptane-1-Methanol, 5,5-Difluoro-, (1S,3R,4R)- (9Ci) is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.