Description

3-Butynoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-,Methylester(9Ci) CAS NO 389599-84-2 is a high-purity, protected amino acid derivative featuring both a terminal alkyne and a tert-butyloxycarbonyl (Boc) protecting group. This compound is a versatile and critical building block in organic synthesis, enabling the construction of complex molecules through click chemistry and peptide coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioconjugates and materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptide mimetics.
• Click Chemistry Reagent: The terminal alkyne moiety allows for efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages in bioconjugation and polymer science.
• Peptide Synthesis: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis, where the Boc group provides orthogonal protection.
• Chemical Biology Probes: Used to create labeled probes for studying protein-protein interactions, enzyme activity, and cellular processes.
• Material Science: Incorporated into polymers and dendrimers to introduce functional handles for further modification or to impart specific material properties.
• Agrochemical Research: Employed in the research and development of new crop protection agents and plant growth regulators.

Basic Information

Product Name	3-Butynoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-,Methylester(9Ci)
CAS No.	389599-84-2
Molecular Formula	C11H17NO4
Molecular Weight	227.26 g/mol
Synonyms	Boc-Propagylglycine-OMe; Methyl 2-[(tert-butoxycarbonyl)amino]but-3-ynoate; 2-[(tert-Butoxycarbonyl)amino]-3-butynoic acid methyl ester; (2S)-2-[(tert-Butoxycarbonyl)amino]but-3-ynoic acid methyl ester; (R)-2-((tert-Butoxycarbonyl)amino)but-3-ynoic acid methyl ester; Boc-D-Propagylglycine-OMe; Boc-L-Propagylglycine-OMe; Methyl N-Boc-2-amino-3-butynoate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data including HPLC, NMR, and MS to verify identity and purity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results for all critical parameters. Our quality management system supports the needs of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation (Optical Purity)	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.