Description

1,8-Naphthyridine-3-Carboxamide,n-[3-(1-Methylethoxy)Phenyl]-2-(Trifluoromethyl)-(9Ci) is a high-value, specialized organic compound featuring a naphthyridine core functionalized with a carboxamide group and a trifluoromethyl substituent. This molecular architecture makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients. The compound, identified by CAS No. 388565-58-0, is supplied under stringent quality controls to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis due to its privileged naphthyridine structure and the presence of the trifluoromethyl group, which often enhances metabolic stability and bioavailability.
• Agrochemical Development: Employed in the research and development of new-generation herbicides, fungicides, or insecticides, where the naphthyridine moiety can contribute to novel modes of action.
• Chemical Biology Probe Synthesis: Utilized for creating molecular probes to study biological pathways and protein functions in academic and industrial research settings.
• Material Science Research: Potential building block for developing organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated system and coordinating ability.

Basic Information

Product Name	1,8-Naphthyridine-3-Carboxamide,n-[3-(1-Methylethoxy)Phenyl]-2-(Trifluoromethyl)-(9Ci)
CAS No.	388565-58-0
Molecular Formula	C19H16F3N3O2
Molecular Weight	375.35 g/mol
Synonyms	N-[3-(Isopropoxy)phenyl]-2-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide; 2-(Trifluoromethyl)-N-[3-(propan-2-yloxy)phenyl]-1,8-naphthyridine-3-carboxamide; 388565-58-0; 1,8-Naphthyridine-3-carboxamide, N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)-; N-(3-Isopropoxyphenyl)-2-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-3-Carboxamide derivative is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or development specifications. Our quality protocols are designed to meet the exacting standards of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.