Description

Benzene, 1-Bromo-4-(2-Methoxyethoxy)-2-[2-(Trimethylsilyl)Ethynyl]- is a specialized aromatic compound featuring a bromo substituent, a methoxyethoxy side chain, and a trimethylsilyl-protected ethynyl group, making it a versatile and valuable advanced intermediate in organic synthesis. Its unique structure is engineered for precise functionalization, enabling the construction of complex molecular architectures. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors, where it facilitates the development of novel active ingredients and functional polymers.

Application

This compound serves as a critical synthon in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Organic Light-Emitting Diode (OLED) Materials: Used in the development of electron-transporting or host materials for display and lighting technologies.
• Liquid Crystal and Polymer Synthesis: Acts as a monomer or precursor for creating advanced polymers with specific optical or electronic properties.
• Agrochemical Research: Intermediate in the design and synthesis of novel herbicides or plant growth regulators.
• Cross-Coupling Reactions: The bromo and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki, and other palladium-catalyzed coupling reactions.
• Material Science Research: Used in the creation of molecular wires, sensors, and other functional nanostructures.
• Protecting Group Strategy: The trimethylsilyl (TMS) group can be selectively removed, allowing for further elaboration of the ethynyl functionality.

Basic Information

Item	Details
Product Name	Benzene, 1-Bromo-4-(2-Methoxyethoxy)-2-[2-(Trimethylsilyl)Ethynyl]-
CAS No.	388111-05-5
Molecular Formula	C14H19BrO2Si
Molecular Weight	327.29 g/mol
Synonyms	1-Bromo-4-(2-methoxyethoxy)-2-((trimethylsilyl)ethynyl)benzene; 2-Bromo-5-(2-methoxyethoxy)-1-((trimethylsilyl)ethynyl)benzene; 1-Bromo-2-ethynyl-4-(2-methoxyethoxy)benzene, TMS-protected; [2-Bromo-5-(2-methoxyethoxy)phenyl]ethynyltrimethylsilane; TMS-Ethynyl Bromo Methoxyethoxy Benzene; Bromo(2-methoxyethoxy)(trimethylsilylethynyl)benzene
EINECS	Contact for details

Quality Control

Our production of Benzene, 1-Bromo-4-(2-Methoxyethoxy)-2-[2-(Trimethylsilyl)Ethynyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment, supporting compliance with internal quality standards and regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.