Description

Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 6-Fluoro-2-Oxo-, (1S,5S,6S)- (9Ci) is a high-purity, stereochemically defined bicyclic fluorinated building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures with precise three-dimensional control, particularly in the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D and fine chemical synthesis laboratories need this material for its unique structural features that enable the exploration of new chemical space and the synthesis of potent, selective drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug discovery.
• Advanced Organic Synthesis: Serves as a versatile, fluorinated bicyclic scaffold for constructing complex natural product analogs and other bioactive molecules.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to investigate the impact of a rigid, fluorinated core on biological activity and metabolic stability.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target drug substances.
• Chemical Biology Probes: Acts as a component in the design of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Research: Potential intermediate for the synthesis of novel, high-performance crop protection agents with unique modes of action.

Basic Information

Item	Details
Product Name	Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 6-Fluoro-2-Oxo-, (1S,5S,6S)- (9Ci)
CAS No.	385368-06-9
Molecular Formula	C7H7FO3
Molecular Weight	158.13 g/mol
Synonyms	(1S,5S,6S)-6-Fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylic acid; (1S,5S,6S)-6-Fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylic Acid; 6-Fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylic acid, (1S,5S,6S)-; Bicyclo[3.1.0]hexane-6-carboxylic acid, 6-fluoro-2-oxo-, (1S,5S,6S)-; (1S,5S,6S)-6-Fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylate; 385368-06-9; (1S,5S,6S)-6-Fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxylic acid (enantiomer)
EINECS	Contact for details

Quality Control

Our Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 6-Fluoro-2-Oxo-, (1S,5S,6S)- (9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification by HPLC, to confirm identity and specification compliance. Certificates of Analysis (COA) detailing all test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.