Description

Isopropyl 8-Methyl-4-Oxo-6-(p-Tolyl)-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 384351-63-7. This compound is valued for its role as a key building block in the synthesis of complex heterocyclic molecules, offering significant value in research and development pipelines. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Research: Serves as a key scaffold for developing new-generation pesticides and herbicides due to its fused pyrimidothiazine structure.
• Organic Synthesis Building Block: Used in academic and industrial research for constructing complex heterocyclic libraries for high-throughput screening.
• Material Science Precursor: Potential application in the development of organic semiconductors or specialty polymers requiring specific nitrogen and sulfur-containing heterocycles.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client-specific molecules.

Basic Information

Product Name	Isopropyl 8-Methyl-4-Oxo-6-(p-Tolyl)-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate
CAS No.	384351-63-7
Molecular Formula	C20H22N2O3S
Molecular Weight	370.47 g/mol
Synonyms	Isopropyl 8-methyl-4-oxo-6-(4-methylphenyl)-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-7-carboxylate; 7-Carboxylic acid, 3,4-dihydro-8-methyl-4-oxo-6-(4-methylphenyl)-2H,6H-pyrimido[2,1-b][1,3]thiazine-, 1-methylethyl ester; 384351-63-7; 6-(4-Methylphenyl)-8-methyl-4-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-7-carboxylic acid isopropyl ester; Pyrimido[2,1-b][1,3]thiazine-7-carboxylate derivative
EINECS	Contact for details

Quality Control

Our Isopropyl 8-Methyl-4-Oxo-6-(p-Tolyl)-3,4-Dihydro-2H,6H-Pyrimido[2,1-B][1,3]Thiazine-7-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.