Description

(S)-tert-Butyl 2-Acetoxy-3-Methylbutanoate is a high-purity chiral ester building block of significant importance in asymmetric synthesis. Its primary value lies in serving as a key protected intermediate for the construction of complex molecules, particularly in the pharmaceutical sector. This compound is essential for researchers and manufacturers in fine chemical, agrochemical, and advanced material industries who require enantiomerically pure intermediates for developing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral and anti-inflammatory drug candidates.
• Asymmetric Synthesis: Used as a building block in stereoselective reactions, including aldol condensations and nucleophilic substitutions, to introduce chiral centers.
• Peptidomimetics Research: Serves as a protected amino acid derivative for constructing peptide analogs and mimetics in medicinal chemistry.
• Agrochemical Synthesis: Employed in the development of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Catalyst Ligand Preparation: Acts as a precursor for synthesizing chiral ligands used in homogeneous catalysis.
• Flavor & Fragrance Industry: Potential use as an intermediate for creating stereospecific flavor compounds and aroma chemicals.

Basic Information

Product Name	(S)-tert-Butyl 2-Acetoxy-3-Methylbutanoate
CAS No.	380886-48-6
Molecular Formula	C11H20O4
Molecular Weight	216.27 g/mol
Synonyms	(S)-2-(Acetyloxy)-3-methylbutanoic acid 1,1-dimethylethyl ester; (S)-O-tert-Butyl 2-acetoxyisovalerate; (S)-tert-Butyl 2-acetoxy-3-methylbutyrate; (S)-2-Acetoxy-3-methylbutyric acid tert-butyl ester; (S)-O-t-Butyl 2-acetoxyisovalerate; (S)-2-Acetoxyisovaleric acid tert-butyl ester; tert-Butyl (S)-2-acetoxy-3-methylbutanoate; (S)-Boc-protected acetoxy valine derivative
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 2-Acetoxy-3-Methylbutanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.