Description

Butanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-3-Methyl-, 1,1-Dimethylethyl Ester, (2R)- is a high-purity, chiral chemical intermediate of significant importance in advanced organic synthesis. This compound matters because its specific stereochemistry and protected functional groups make it a valuable building block for creating complex, optically active molecules. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, particularly in stereoselective reactions.
• Peptidomimetic Research: Used in the construction of peptide analogs and protease inhibitors due to its phthalimido-protected amino acid derivative structure.
• Asymmetric Synthesis: Serves as a starting material or intermediate for catalysts and ligands used in enantioselective catalysis.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals requiring high enantiomeric purity.
• Academic & R&D: Utilized in chemical research for method development and exploring new synthetic pathways.

Basic Information

Product Name	Butanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-3-Methyl-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	380886-38-4
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	(R)-2-((1,3-Dioxoisoindolin-2-yl)oxy)-3-methylbutanoic acid tert-butyl ester; tert-Butyl (2R)-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-3-methylbutanoate; (R)-N-Phthaloyl-O-tert-butylisoleucine; (R)-2-(1,3-Dioxoisoindolin-2-yloxy)-3-methylbutyric acid tert-butyl ester; O-tert-Butyl-N-phthaloyl-(R)-isoleucine; (2R)-2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-3-methylbutanoic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our Butanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-3-Methyl-, 1,1-Dimethylethyl Ester, (2R)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.