Description

Propanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-, 1,1-Dimethylethyl Ester, (2R)- is a high-purity, single-enantiomer chemical intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key chiral building block, enabling the production of optically active pharmaceuticals and fine chemicals with high stereoselectivity. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop and manufacture novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of enantiomerically pure drugs.
• Agrochemical Synthesis: Used in the research and production of advanced, stereospecific pesticides and herbicides.
• Asymmetric Catalysis: Serves as a precursor or ligand in catalytic systems designed for stereoselective chemical transformations.
• Fine Chemical Production: Employed in the manufacture of complex, high-value specialty chemicals where optical purity is paramount.
• Peptidomimetic Research: Acts as a protected amino acid derivative in the design and synthesis of peptide analogs and protease inhibitors.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	Propanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	380886-36-2
Molecular Formula	C16H19NO5
Molecular Weight	305.33 g/mol
Synonyms	(R)-N-Phthaloyl-O-tert-butylserine; (R)-2-[(1,3-Dioxoisoindolin-2-yl)oxy]-3,3-dimethylbutanoic acid; (2R)-2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]-3,3-dimethylbutanoic acid; tert-Butyl (R)-N-phthaloylserinate; O-(1,3-Dioxoisoindolin-2-yl)-D-O-tert-butylserine; (R)-N-Phthaloyl-O-t-butylserine; (R)-O-(1,3-Dioxoisoindolin-2-yl)-3,3-dimethylbutanoic acid; D-N-Phthaloyl-O-tert-butylserine
EINECS	Contact for details

Quality Control

Our Propanoic Acid, 2-[(1,3-Dihydro-1,3-Dioxo-2H-Isoindol-2-Yl)Oxy]-, 1,1-Dimethylethyl Ester, (2R)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure high chemical and optical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.