Description

4-(9H-Fluoren-9-Yl)-n-(3,4,5-Trimethoxybenzylidene)Piperazin-1-Amine CAS NO 380452-74-4 is a high-purity, advanced pharmaceutical intermediate characterized by its complex molecular architecture combining fluorene and trimethoxyphenyl moieties. This compound is critical for research and development in medicinal chemistry, offering a versatile scaffold for the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Oncology Drug Discovery: Investigated for the development of potential anticancer agents due to the biological activity profiles of its structural components.
• CNS-Targeted Compound Libraries: Employed in the creation of compound libraries targeting neurological disorders.
• Chemical Biology Probes: Utilized in the design of molecular probes to study biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(9H-Fluoren-9-Yl)-n-(3,4,5-Trimethoxybenzylidene)Piperazin-1-Amine
CAS No.	380452-74-4
Molecular Formula	C30H31N3O3
Molecular Weight	481.59 g/mol
Synonyms	4-(9H-Fluoren-9-yl)-N-[(3,4,5-trimethoxyphenyl)methylidene]piperazin-1-amine; 1-[(3,4,5-Trimethoxybenzylidene)amino]-4-(9H-fluoren-9-yl)piperazine; 380452-74-4; 4-(Fluoren-9-yl)-N-(3,4,5-trimethoxybenzylidene)piperazin-1-amine; N-(3,4,5-Trimethoxybenzylidene)-4-(9H-fluoren-9-yl)-1-piperazinamine
EINECS	Contact for details

Quality Control

Our 4-(9H-Fluoren-9-Yl)-n-(3,4,5-Trimethoxybenzylidene)Piperazin-1-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.