Description

Nelotanserin is a potent and selective inverse agonist for the 5-HT2A receptor, representing a significant compound in central nervous system research. Its primary value lies in its targeted mechanism of action, which has been investigated for potential therapeutic applications in sleep disorders and other neurological conditions. This high-purity intermediate is essential for pharmaceutical R&D teams, medicinal chemists, and contract manufacturing organizations (CMOs) engaged in the development of novel neuropsychiatric therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting serotonin receptors.
• Neurological Research: Used as a reference standard and tool compound in preclinical studies investigating 5-HT2A receptor function and modulation.
• Sleep Disorder R&D: Critical for research programs focused on developing new treatments for insomnia and REM sleep behavior disorder.
• Medicinal Chemistry: Serves as a core scaffold for the design and synthesis of novel chemical entities with potential CNS activity.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and binding assays to characterize receptor-ligand interactions.
• GMP Manufacturing: Supplied as a qualified starting material for cGMP production under controlled regulatory pathways.

Basic Information

Product Name	Nelotanserin
CAS No.	380449-54-7
Molecular Formula	C24H25FN4O2
Molecular Weight	420.48 g/mol
Synonyms	Nelotanserin; APD-125; 4-Fluoro-N-[6-[(1-methyl-4-piperidinyl)oxy]-3-pyridinyl]-N-propylbenzenesulfonamide; 4-Fluoro-N-[6-[(1-methylpiperidin-4-yl)oxy]pyridin-3-yl]-N-propylbenzenesulfonamide; APD125; BGC20-1001; RVX-1001; BGC 20-1001
EINECS	Contact for details

Quality Control

Our Nelotanserin is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.