Description

(2S,4R)-3-tert-Butyl 4-Methyl 2-tert-Butyloxazolidine-3,4-Dicarboxylate is a high-purity, chiral oxazolidine derivative that serves as a critical building block in asymmetric synthesis. Its primary value lies in its role as a versatile chiral auxiliary and intermediate for constructing complex, stereochemically defined molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality chiral intermediates to accelerate their R&D pipelines and scale-up processes.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand to induce stereoselectivity in aldol, alkylation, and conjugate addition reactions.
• Peptidomimetics & Protease Inhibitors: Core scaffold for developing novel peptidomimetic compounds and inhibitors of various proteases.
• Agrochemical Synthesis: Intermediate in the production of chiral herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: Used in research laboratories for method development and exploring new synthetic routes to complex natural products.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	(2S,4R)-3-tert-Butyl 4-Methyl 2-tert-Butyloxazolidine-3,4-Dicarboxylate
CAS No.	380429-42-5
Molecular Formula	C15H27NO5
Molecular Weight	301.38 g/mol
Synonyms	(2S,4R)-3-(tert-Butoxycarbonyl)-4-(methoxycarbonyl)-2-(tert-butyl)-1,3-oxazolidine; (2S,4R)-2-tert-Butyl-3-(tert-butoxycarbonyl)-4-(methoxycarbonyl)oxazolidine; (2S,4R)-2-tert-Butyl-3-Boc-4-(COOMe)-oxazolidine; Boc-Derived Chiral Oxazolidine Ester; (2S,4R)-Boc-Protected Oxazolidine Dicarboxylate; (2S,4R)-3-Boc-4-Methyl 2-tert-Butyloxazolidine-3,4-dicarboxylate; Chiral Oxazolidine Auxiliary
EINECS	Contact for details

Quality Control

Our production of (2S,4R)-3-tert-Butyl 4-Methyl 2-tert-Butyloxazolidine-3,4-Dicarboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and ISO 9001 standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.