Description

Ethyl 2-Oxo-4-(Trimethylsilyl)But-3-Ynoate is a specialized organosilicon building block featuring a unique combination of a silyl-protected alkyne and a β-ketoester moiety. This compound is valued for its versatility as a key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a crucial synthon for the synthesis of novel drug candidates, particularly in the development of heterocyclic compounds and complex natural product analogs.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products, leveraging its reactive functional groups.
• Material Science Research: Acts as a precursor for silicon-containing polymers or advanced organic frameworks with tailored electronic or optical properties.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic chemistry, including cycloaddition reactions and cross-coupling protocols.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and high-value flavor & fragrance ingredients.

Basic Information

Product Name	Ethyl 2-Oxo-4-(Trimethylsilyl)But-3-Ynoate
CAS No.	379224-67-6
Molecular Formula	C11H18O3Si
Molecular Weight	226.34 g/mol
Synonyms	Ethyl 4-(Trimethylsilyl)-2-oxobut-3-ynoate; 4-(Trimethylsilyl)-2-oxo-3-butynoic Acid Ethyl Ester; Ethyl 2-Oxo-4-(trimethylsilyl)-3-butynoate; TMS-Propargylic β-Ketoester; But-3-ynoic acid, 2-oxo-4-(trimethylsilyl)-, ethyl ester; Ethyl (Trimethylsilyl)propiolylacetate; 379224-67-6
EINECS	Contact for details

Quality Control

Our Ethyl 2-Oxo-4-(Trimethylsilyl)But-3-Ynoate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles for production where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.