Description

3-(2-Chloro-4-Fluoro-Phenyl)-Propionic Acid Ethyl Ester is a high-purity fluorinated aromatic ester building block of significant importance in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific halogenated phenylpropionate structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Synthesis: Serves as a key precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators, leveraging the bioactivity of the fluorinated aromatic moiety.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated organic compounds for electronic applications, including liquid crystal displays and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, catalysis studies, and exploring new synthetic pathways involving ester and aryl halide functionalities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches under cGMP conditions.

Basic Information

Product Name	3-(2-Chloro-4-Fluoro-Phenyl)-Propionic Acid Ethyl Ester
CAS No.	377083-93-7
Molecular Formula	C11H12ClFO2
Molecular Weight	230.66 g/mol
Synonyms	Ethyl 3-(2-Chloro-4-fluorophenyl)propionate; 2-Chloro-4-fluorophenylpropionic Acid Ethyl Ester; 3-(2-Chloro-4-fluorophenyl)propanoic Acid Ethyl Ester; Ethyl (2-Chloro-4-fluorophenyl)propionate; 377083-93-7; NSC 405124; AI3-52062; ZINC000004082756
EINECS	Contact for details

Quality Control

Our 3-(2-Chloro-4-Fluoro-Phenyl)-Propionic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring material that meets internal quality standards or specific regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.