Description

T-Butyl 3-Bromo-4-Fluorobenzoate is a high-purity, synthetically valuable benzoate ester derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in providing a protected carboxylic acid group and halogenated aromatic ring system, enabling precise molecular construction for complex target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those containing fluorinated and brominated aromatic motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the 3-bromo-4-fluorophenyl moiety is a required structural component.
• Ligand and Material Science: Serves as a starting material for synthesizing specialized ligands for catalysis or as a monomer for creating functionalized polymers and advanced materials.
• Chemical Research & Development: Employed in academic and industrial R&D for method development, exploring new coupling reactions, and creating compound libraries for screening.
• Custom Synthesis Building Block: Provides a versatile platform for medicinal chemistry, allowing for further functionalization at the ester and halogen sites to explore structure-activity relationships (SAR).

Basic Information

Product Name	T-Butyl 3-Bromo-4-Fluorobenzoate
CAS No.	375368-94-8
Molecular Formula	C11H12BrFO2
Molecular Weight	275.12 g/mol
Synonyms	tert-Butyl 3-bromo-4-fluorobenzoate; 3-Bromo-4-fluorobenzoic acid tert-butyl ester; 4-Fluoro-3-bromobenzoic acid tert-butyl ester; Benzoic acid, 3-bromo-4-fluoro-, 1,1-dimethylethyl ester; tert-Butyl 4-fluoro-3-bromobenzoate; 1,1-Dimethylethyl 3-bromo-4-fluorobenzoate; TB-3-Br-4-F-Benzoate
EINECS	Contact for details

Quality Control

Our T-Butyl 3-Bromo-4-Fluorobenzoate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.