Description

1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic scaffold.
• API Development: Serves as a precursor in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Synthesis: Potential application in the development of protease inhibitor compounds.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for biological target identification.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.

Basic Information

Product Name	1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	374796-29-9
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	tert-Butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 9-Boc-4-hydroxy-1-oxa-9-azaspiro[5.5]undecane; 4-Hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester; Boc-protected 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane; (4-Hydroxy-1-oxa-9-azaspiro[5.5]undecan-9-yl)-tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our 1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.