Description

1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 3-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of next-generation drugs, including central nervous system (CNS) agents and other specialized therapeutics.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of complex drug molecules, especially those with spirocyclic architectures.
• Research & Development (R&D): Used in medicinal chemistry for lead optimization and the creation of new chemical entities (NCEs) with potential biological activity.
• API Manufacturing: Employed in the scaled-up production of active pharmaceutical ingredients for preclinical and clinical studies.
• CNS Drug Development: Its structural features make it a valuable precursor in the synthesis of compounds targeting neurological disorders.
• Custom Synthesis Projects: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule assembly.

Basic Information

Product Name	1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 3-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	374795-42-3
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	tert-Butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 9-Boc-3-hydroxy-1-oxa-9-azaspiro[5.5]undecane; 3-Hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester; Boc-protected 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane; Spirocyclic amino alcohol Boc ester
EINECS	Contact for details

Quality Control

Our 1-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylic Acid, 3-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.