Description

2-Oxa-7-Azaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of API manufacturing routes.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic structure can be incorporated into linkers or warheads for the design of targeted protein degraders.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Oxa-7-Azaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester
CAS No.	374795-36-5
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	tert-Butyl 2-oxa-7-azaspiro[4.5]decane-7-carboxylate; 7-Boc-2-oxa-7-azaspiro[4.5]decane; 2-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 2-oxa-7-azaspiro[4.5]decane-7-carboxylate; Boc-2-oxa-7-azaspiro[4.5]decane; 7-(tert-Butoxycarbonyl)-2-oxa-7-azaspiro[4.5]decane; Spirocyclic Boc-protected amine ether.
EINECS	Contact for details

Quality Control

Our 2-Oxa-7-Azaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and aligns with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.