Description

1,1-Dimethylethyl 1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries seeking to build sophisticated molecular architectures with high stereochemical control.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel therapeutic agents, especially in neurological and antiviral drug discovery pipelines.
• Organic Synthesis Reagent: Used in the construction of complex spirocyclic and heterocyclic frameworks prevalent in modern medicinal chemistry.
• Process Chemistry: Serves as a crucial starting material or intermediate in the scale-up and optimization of API manufacturing processes under GMP conditions.
• Research & Development: Employed in academic and industrial R&D labs for exploring new chemical spaces and developing proprietary synthetic methodologies.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals requiring high-purity, structurally defined intermediates.

Basic Information

Product Name	1,1-Dimethylethyl 1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate
CAS No.	374794-89-5
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	tert-Butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-Boc-1-oxa-8-azaspiro[4.5]decane; 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 8-(tert-Butoxycarbonyl)-1-oxa-8-azaspiro[4.5]decane; Boc-1-oxa-8-azaspiro[4.5]decane; 374794-89-5; tert-Butyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate
EINECS	Contact for details

Quality Control

Our 1,1-Dimethylethyl 1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each lot, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed in a dry environment to protect the integrity of the product.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.