Description

2,2-Dimethyl-Propanoic Acid [(1R,5S)-4-Hydroxy-6,6-Dimethylbicyclo[3.1.1]Hept-2-En-2-Yl]Methyl Ester is a high-purity, chiral bicyclic ester derivative of pivalic acid, valued for its unique structural framework and stereochemical precision. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in asymmetric synthesis, enabling the development of complex molecules with defined three-dimensional architecture. It is primarily required by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in therapeutic areas requiring complex, constrained molecular scaffolds.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the bicyclo[3.1.1]heptane moiety, a structure of interest in medicinal chemistry.
• Agrochemical Research: Intermediate in the development of new-generation pesticides and herbicides with enhanced specificity and activity.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, flavors, and fragrances requiring high stereochemical purity.
• Material Science: Potential monomer or cross-linking agent for creating polymers with specific thermal or mechanical properties derived from its rigid bicyclic structure.
• Academic & R&D: Used in research laboratories for methodological studies in organic synthesis and catalysis.

Basic Information

Product Name	2,2-Dimethyl-Propanoic Acid [(1R,5S)-4-Hydroxy-6,6-Dimethylbicyclo[3.1.1]Hept-2-En-2-Yl]Methyl Ester
CAS No.	374559-42-9
Molecular Formula	C15H24O3
Molecular Weight	252.35 g/mol
Synonyms	(1R,5S)-4-Hydroxy-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-ylmethyl pivalate; Pivalic acid [(1R,5S)-4-hydroxy-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl]methyl ester; (1R,5S)-Verbenyl pivalate; 4-Hydroxy-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-ylmethyl 2,2-dimethylpropanoate; Bicyclo[3.1.1]hept-2-ene-2-methanol, 4-hydroxy-6,6-dimethyl-, 2,2-dimethylpropanoate, (1R,5S)-
EINECS	Contact for details

Quality Control

Our production of 2,2-Dimethyl-Propanoic Acid [(1R,5S)-4-Hydroxy-6,6-Dimethylbicyclo[3.1.1]Hept-2-En-2-Yl]Methyl Ester adheres to stringent cGMP and ISO 9001 guidelines, ensuring batch-to-batch consistency and traceability. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet exacting customer specifications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.