Description

2,2-Diphenylethylisocyanide is a specialized organic isocyanide building block of significant interest in synthetic chemistry. This compound matters for its role as a versatile ligand and precursor in the construction of complex molecular architectures, particularly in transition metal catalysis and multicomponent reactions. Pharmaceutical, agrochemical, and advanced materials research laboratories require this high-purity intermediate to develop novel compounds and catalytic systems. Its unique structure facilitates the synthesis of heterocycles and functionalized molecules critical for drug discovery and material science applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Catalysis & Ligand Chemistry: Acts as a versatile ligand for transition metals, enabling catalytic cycles in cross-coupling and other metal-mediated organic transformations.
• Multicomponent Reaction (MCR) Substrate: Used in Passerini and Ugi-type reactions for the efficient, one-pot synthesis of complex amides and heterocyclic compounds.
• Agrochemical Research: Employed in the development of new pesticides and herbicides, leveraging its isocyanide functionality.
• Material Science & Polymer Chemistry: A precursor for functional polymers and smart materials, including metal-organic frameworks (MOFs) and sensors.
• Academic & Process R&D: A valuable reagent for methodological development and exploring new synthetic pathways in research laboratories.

Basic Information

Item	Details
Product Name	2,2-Diphenylethylisocyanide
CAS No.	374081-26-2
Molecular Formula	C15H13N
Molecular Weight	207.27 g/mol
Synonyms	2,2-Diphenylethyl isocyanide; (2-Isocyanoethyl)diphenylmethane; α-Isocyanato-α,α-diphenylethane (common misnomer); Diphenylmethyl isocyanide; Isocyanomethyldiphenylmethane; 2,2-Diphenylethane isonitrile; NSC 83616; (Diphenylmethyl)methyl isocyanide
EINECS	Contact for details

Quality Control

Every batch of 2,2-Diphenylethylisocyanide is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and research materials. Comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat sources and open flame. Keep under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.