Description

Acetic-D3 Acid, 2,5-Dioxopyrrolidin-1-Yl Ester is a deuterated active ester derivative of acetic acid, specifically designed for advanced synthetic and analytical applications. This compound is a critical reagent for introducing a deuterated acetyl group (CD3CO-) into target molecules, enabling precise isotopic labeling. It is essential for researchers and manufacturers in pharmaceutical development, metabolic studies, and advanced material science where deuterium labeling is required for tracking, stability enhancement, or spectroscopic analysis.

Application

• Deuterium Labeling in Pharmaceutical R&D: Used as a key intermediate for synthesizing deuterated drug candidates to study pharmacokinetics, metabolic pathways, and to potentially improve drug stability and half-life.
• Proteomics and Mass Spectrometry: Serves as a labeling reagent for chemical proteomics, enabling quantitative mass spectrometry analysis of proteins and peptides.
• NMR Spectroscopy Standards: Acts as a useful reagent for preparing internal standards and reference compounds for Nuclear Magnetic Resonance (NMR) spectroscopy.
• Organic Synthesis Building Block: Employed in peptide coupling and acylation reactions where a deuterated acetyl moiety is required, leveraging the reactivity of the N-hydroxysuccinimide (NHS) ester group.
• Material Science Research: Utilized in the synthesis of deuterated polymers or small molecules for studying structure-property relationships and dynamics.
• Metabolic Pathway Tracing: Applied in biochemical research to trace and quantify metabolic fluxes using stable isotope labeling techniques.

Basic Information

Product Name	Acetic-D3 Acid, 2,5-Dioxopyrrolidin-1-Yl Ester
CAS No.	372942-43-3
Molecular Formula	C6H4D3NO4
Molecular Weight	160.13 g/mol
Synonyms	Acetic-d3 acid N-hydroxysuccinimide ester; Acetic-d3 acid NHS ester; Acetic-d3 acid N-succinimidyl ester; CD3COOSu; N-Succinimidyl acetate-d3; N-Hydroxysuccinimide-d3 acetate; Deuterated Acetic Acid NHS Ester; [2,5-Dioxopyrrolidin-1-yl] acetate-d3; N-Acetoxysuccinimide-d3
EINECS	Contact for details

Quality Control

Our Acetic-D3 Acid, 2,5-Dioxopyrrolidin-1-Yl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) detailing purity, assay, deuterium content, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Content (NMR)	≥ 99 atom % D
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.