Description

1,4-Dioxaspiro[4.5]Decane-8-Carboxylicacid,8-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-(9Ci) is a sophisticated, high-purity chemical building block featuring a protected amino acid moiety. This compound is of critical importance in peptide synthesis and pharmaceutical research, where it serves as a key intermediate for constructing complex molecular architectures. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on advanced drug discovery and development programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative for the sequential assembly of peptides.
• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in the design and synthesis of compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Bioconjugation: Employed in the chemical modification of proteins, antibodies, or other biomolecules to introduce specific functional handles.
• Organic Synthesis: Serves as a versatile chiral synthon for constructing complex natural products and heterocyclic compounds.
• Proteomics and Biochemical Research: Utilized in the preparation of enzyme substrates, inhibitors, or labeled probes.

Basic Information

Product Name	1,4-Dioxaspiro[4.5]Decane-8-Carboxylicacid,8-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-(9Ci)
CAS No.	369403-24-7
Molecular Formula	C24H25NO6
Molecular Weight	423.46 g/mol
Synonyms	Fmoc-8-Amino-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; Fmoc-Adoo-OH; 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; N-Fmoc-1,4-dioxaspiro[4.5]decane-8-carboxylic acid, 8-amino-; 8-(Fmoc-amino)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; Fmoc-protected cyclopentane spirolactone amino acid; (8-Amino-1,4-dioxaspiro[4.5]decan-8-yl)-carbamic acid 9H-fluoren-9-ylmethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for applications in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.