Description

1-(Difluoro-Trimethylsilyl-Methyl)-4-Dimethylamino-Pyridinium Triflate is a specialized organosilicon reagent featuring a reactive difluoromethylsilyl group activated by a pyridinium leaving group. This compound is a highly effective nucleophilic difluoromethylation agent, enabling the efficient introduction of the valuable difluoromethylene (CF2) unit into complex molecular frameworks. It is primarily utilized by pharmaceutical and agrochemical R&D organizations for the synthesis of novel bioactive compounds, where the incorporation of fluorine atoms is critical for modulating metabolic stability, lipophilicity, and binding affinity.

Application

• Nucleophilic Difluoromethylation Reagent: Key intermediate for introducing the -CF2- group into organic molecules under mild conditions.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates containing fluorinated motifs.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides with enhanced properties.
• Material Science Research: Precursor for creating fluorinated functional materials and specialty polymers.
• Medicinal Chemistry & Drug Discovery: A critical tool for lead optimization and structure-activity relationship (SAR) studies in fluorinated compound libraries.
• Process Chemistry Development: Used in scaling up synthetic routes for fluorinated target molecules.

Basic Information

Product Name	1-(Difluoro-Trimethylsilyl-Methyl)-4-Dimethylamino-Pyridinium Triflate
CAS No.	368873-80-7
Molecular Formula	C12H19F5N2O3SSi
Molecular Weight	394.44 g/mol
Synonyms	4-(Dimethylamino)-1-[(difluoro)(trimethylsilyl)methyl]pyridinium trifluoromethanesulfonate; 1-[(Difluoro)(trimethylsilyl)methyl]-4-(dimethylamino)pyridinium triflate; (Difluoromethyl)trimethylsilane-DMAP Complex Triflate; DFTSM-DMAP Triflate; Nucleophilic Difluoromethylation Reagent; Ruppert-Prakash Reagent Analogue; TMSCF2-DMAP+ OTf-
EINECS	Contact for details

Quality Control

Our 1-(Difluoro-Trimethylsilyl-Methyl)-4-Dimethylamino-Pyridinium Triflate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 13C, 19F), HPLC, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 compliant production for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) to maintain stability and prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.