Description

Proline, 1-Cyano-, Methyl Ester (9Ci) CAS NO 367906-67-0 is a high-purity, non-proteinogenic amino acid derivative characterized by its cyano and methyl ester functional groups. This compound serves as a versatile and critical chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures with high stereochemical control. It is primarily utilized by research institutions and pharmaceutical development teams engaged in the synthesis of peptidomimetics, active pharmaceutical ingredients (APIs), and specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic research.
• Peptidomimetic Synthesis: Used to introduce constrained proline analogs into peptide chains to enhance metabolic stability and biological activity.
• Agrochemical Research: Serves as a building block for synthesizing advanced, biologically active molecules in crop protection science.
• Academic & R&D Laboratories: Employed in methodological studies and the synthesis of complex natural product analogs and chemical probes.
• Fine Chemical Production: Integral to the custom synthesis of specialty chemicals requiring specific chiral centers and functional group compatibility.

Basic Information

Product Name	Proline, 1-Cyano-, Methyl Ester (9Ci)
CAS No.	367906-67-0
Molecular Formula	C7H10N2O2
Molecular Weight	154.17 g/mol
Synonyms	1-Cyano-L-proline methyl ester; Methyl 1-cyanoproline-2-carboxylate; Methyl 1-cyano-L-prolinate; (S)-Methyl 1-cyanopyrrolidine-2-carboxylate; L-Proline, 1-cyano-, methyl ester; 1-Cyano-L-proline methyl ester; Methyl (S)-1-cyanopyrrolidine-2-carboxylate; 367906-67-0
EINECS	Contact for details

Quality Control

Our Proline, 1-Cyano-, Methyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral excess is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.