Description

Carbamic Acid, [(1R)-1-(Aminocarbonyl)Butyl]-, 1,1-Dimethylethyl Ester (9Ci) is a chiral, protected amino acid derivative of significant interest in advanced organic synthesis. This compound matters as a high-purity, stereochemically defined building block, enabling the precise construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), peptides, and other bioactive molecules where stereochemical integrity is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the preparation of non-natural or modified amino acid residues for peptide-based therapeutics and research.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) group serves as a temporary protecting group for amines in complex synthetic sequences.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric transformations to introduce chiral centers.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged compounds for mechanism-of-action and target identification studies.
• Process Development: Serves as a reference standard or an intermediate in scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Carbamic Acid, [(1R)-1-(Aminocarbonyl)Butyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	367268-60-8
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-norvaline amide; Boc-L-Norvaline amide; (2R)-2-[(tert-Butoxycarbonyl)amino]pentanamide; N-Boc-L-norvalinamide; tert-Butyl (1R)-1-(aminocarbonyl)butylcarbamate; (S)-2-((tert-Butoxycarbonyl)amino)pentanamide; L-Norvaline, N-[(1,1-dimethylethoxy)carbonyl]-, amide; Boc-Nva-NH2
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(1R)-1-(Aminocarbonyl)Butyl]-, 1,1-Dimethylethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting research and pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.