Description

trans-4-Amino-1-n-Boc-3-Pyrrolidinecarboxylic Acid Ethyl Ester is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for constructing complex molecular architectures with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of peptidomimetics and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Peptidomimetic Synthesis: Used to incorporate constrained proline-like structures into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile precursor for the preparation of other chiral amines and carboxylic acid derivatives via selective deprotection and functional group transformations.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Agrochemical Research: Utilized as a building block in the discovery of novel pesticides and herbicides with specific chiral activity.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CRO/CMO settings.

Basic Information

Item	Details
Product Name	trans-4-Amino-1-n-Boc-3-Pyrrolidinecarboxylic Acid Ethyl Ester
CAS No.	362489-56-3
Molecular Formula	C12H22N2O4
Molecular Weight	258.32 g/mol
Synonyms	Ethyl (3R,4R)-4-Amino-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylate; (3R,4R)-1-Boc-4-aminopyrrolidine-3-carboxylic Acid Ethyl Ester; trans-1-N-Boc-4-aminopyrrolidine-3-carboxylic Acid Ethyl Ester; (3R,4R)-4-Amino-1-Boc-pyrrolidine-3-carboxylic Acid Ethyl Ester; 1-Boc-4-amino-3-pyrrolidinecarboxylic Acid Ethyl Ester (trans); trans-4-Amino-1-Boc-pyrrolidine-3-carboxylic Acid Ethyl Ester; 362489-56-3; tert-Butyl (3R,4R)-4-amino-3-(ethoxycarbonyl)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our trans-4-Amino-1-n-Boc-3-Pyrrolidinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.