Description

1,4-Dioxaspiro[4.4]Nonane-7-Carboxylicacid,8-Amino-,Methylester,(7S,8R)-(9Ci) is a high-purity, stereochemically defined spirocyclic amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in its rigid, fused ring system and functional handles, which enable the construction of complex molecular architectures with precise stereocontrol. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including potential protease inhibitors, neurological agents, and antiviral compounds.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides where the specific (7S,8R) configuration is crucial for bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing novel chiral ligands and organocatalysts.
• Peptidomimetics & Constrained Peptide Design: The spirocyclic structure is valuable for introducing conformational constraints into peptide backbones to enhance stability and selectivity.
• Academic & R&D Laboratories: Employed in methodological studies and the exploration of new synthetic routes involving stereoselective transformations.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals requiring this specific, high-value molecular scaffold.

Basic Information

Item	Details
Product Name	1,4-Dioxaspiro[4.4]Nonane-7-Carboxylicacid,8-Amino-,Methylester,(7S,8R)-(9Ci)
CAS No.	362489-00-7
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	(7S,8R)-8-Amino-1,4-dioxaspiro[4.4]nonane-7-carboxylic acid methyl ester; Methyl (7S,8R)-8-amino-1,4-dioxaspiro[4.4]nonane-7-carboxylate; (7S,8R)-Aminospiroketal ester; Spiro[1,4-dioxane-2,1'-cyclopentane]-7-carboxylic acid, 8-amino-, methyl ester, (7S,8R)-; 362489-00-7; Amino-spirocyclic ester; Chiral spiro amino acid methyl ester
EINECS	Contact for details

Quality Control

Our 1,4-Dioxaspiro[4.4]Nonane-7-Carboxylicacid,8-Amino-,Methylester,(7S,8R)-(9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting research and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (7S,8R) isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.