Description

Methyl (R)-(+)-Isocyanato-3-Phenylpropionate is a high-value, chiral isocyanate ester building block. This compound matters for its role in the stereoselective synthesis of complex molecules, where it introduces a protected amine functionality with defined stereochemistry. Pharmaceutical, agrochemical, and advanced material researchers need this reagent for developing active ingredients and chiral polymers.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of β-amino acid derivatives, peptidomimetics, and active pharmaceutical ingredients (APIs) with specific stereocenters.
• Agrochemical Synthesis: Used in creating chiral herbicides, fungicides, and insecticides where the (R)-enantiomer provides the desired biological activity.
• Peptide Chemistry: Serves as a reagent for introducing urethane-protected amine groups in solid-phase and solution-phase peptide synthesis.
• Polymer Science: Monomer for the production of chiral polyurethanes and polyureas with potential applications in specialty coatings and separation membranes.
• Asymmetric Catalysis Research: Valuable substrate for testing and developing new chiral catalysts and methodologies in academic and industrial R&D.
• Ligand and Chiral Auxiliary Preparation: Building block for synthesizing chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.

Basic Information

Product Name	Methyl (R)-(+)-Isocyanato-3-Phenylpropionate
CAS No.	361456-36-2
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(R)-Methyl 3-Isocyanato-3-phenylpropionate; (R)-Methyl 3-Phenyl-3-isocyanatopropanoate; Methyl (3R)-3-Isocyanato-3-phenylpropanoate; (R)-(+)-3-Isocyanato-3-phenylpropionic Acid Methyl Ester; (R)-Methyl β-Isocyanato-β-phenylpropionate; (R)-MHI; (R)-Methyl 3-Phenyl-3-isocyanato-propionate
EINECS	Contact for details

Quality Control

Our Methyl (R)-(+)-Isocyanato-3-Phenylpropionate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Keep away from heat, open flames, and sources of ignition. Allow the container to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.