Description

3-Nitro-6-[2-(Trimethylsilyl)Ethoxy]Pyridine-2-Acetonitrile is a high-value, functionalized pyridine derivative featuring both nitro and trimethylsilyl-protected ethoxy substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the construction of complex nitrogen-containing heterocycles. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for developing novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Building block for creating novel pesticides and herbicides with pyridine-based active moieties.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions.
• Material Science Research: Intermediate for synthesizing organic electronic materials and photoactive compounds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic and Industrial R&D: Utilized in research laboratories for method development and exploring new chemical entities.

Basic Information

Item	Details
Product Name	3-Nitro-6-[2-(Trimethylsilyl)Ethoxy]Pyridine-2-Acetonitrile
CAS No.	361456-00-0
Molecular Formula	C₁₂H₁₇N₃O₃Si
Molecular Weight	279.37 g/mol
Synonyms	2-(3-Nitro-6-((2-(trimethylsilyl)ethoxy)pyridin-2-yl)acetonitrile; 2-(3-Nitro-6-(2-(trimethylsilyl)ethoxy)pyridin-2-yl)acetonitrile; 3-Nitro-6-(2-trimethylsilylethoxy)pyridine-2-acetonitrile; 3-Nitro-6-(2-(trimethylsilyl)ethoxy)-2-pyridineacetonitrile; 2-Pyridineacetonitrile, 3-nitro-6-[2-(trimethylsilyl)ethoxy]-; 361456-00-0; TMS-Protected Nitropyridine Acetonitrile
EINECS	Contact for details

Quality Control

Our 3-Nitro-6-[2-(Trimethylsilyl)Ethoxy]Pyridine-2-Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.