Description

(1S,2S)-2-Benzyloxycyclohexyl Isocyanate is a chiral, enantiomerically pure organic building block featuring a protected hydroxyl group. This compound is a valuable intermediate in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research, where stereochemistry is critical for biological activity. It is primarily used by R&D chemists and process development scientists in fine chemical and active pharmaceutical ingredient (API) manufacturing. The product is supplied with a high level of purity to ensure consistent performance in demanding synthetic applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of enantiomerically pure pesticides and herbicides.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Polymer Modification: Employed to introduce functional isocyanate groups into specialty polymers, such as polyurethanes with tailored properties.
• Peptide Mimetics and Bioconjugation: The reactive isocyanate group allows for coupling with amines to create urea linkages in peptidomimetics or bioconjugates.
• Material Science Research: Used in the synthesis of advanced organic materials and liquid crystals.

Basic Information

Item	Details
Product Name	(1S,2S)-2-Benzyloxycyclohexyl Isocyanate
CAS No.	361392-21-4
Molecular Formula	C14H17NO2
Molecular Weight	231.29 g/mol
Synonyms	(1S,2S)-2-(Benzyloxy)cyclohexyl isocyanate; trans-2-(Benzyloxy)cyclohexyl isocyanate; (1S,2S)-2-(Phenylmethoxy)cyclohexyl isocyanate; 2-Benzyloxycyclohexyl isocyanate, (1S,2S)-; Cyclohexanol, 2-(benzyloxy)-, 1-isocyanate-, (1S,2S)-; Benzyl (1S,2S)-2-isocyanatocyclohexyl ether
EINECS	Contact for details

Quality Control

Our (1S,2S)-2-Benzyloxycyclohexyl Isocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically exceeding 98% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles for pharmaceutical intermediates, and our quality system is designed to meet the stringent requirements of research and commercial-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.