Description

(S)-Ethyl 4-Oxo-1-((R)-1-Phenylethyl)Piperidine-2-Carboxylate CAS NO 357154-19-9 is a high-purity chiral piperidine derivative, a critical building block in modern asymmetric synthesis. Its defined stereochemistry is essential for creating enantiomerically pure compounds, directly impacting the efficacy and safety profile of the final product. This intermediate is primarily required by pharmaceutical R&D and production teams for the development of active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially for neurological and psychiatric targets.
• Asymmetric Catalysis Research: Serves as a precursor or ligand in the development of novel catalytic systems for stereoselective transformations.
• API Development: Used in the research and process development of new Active Pharmaceutical Ingredients (APIs) requiring specific stereocenters.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged compounds for studying biological pathways and target engagement.
• Process Chemistry Optimization: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Custom Synthesis & Contract Manufacturing: A fundamental component for CDMOs (Contract Development and Manufacturing Organizations) offering bespoke chemical synthesis services.

Basic Information

Product Name	(S)-Ethyl 4-Oxo-1-((R)-1-Phenylethyl)Piperidine-2-Carboxylate
CAS No.	357154-19-9
Molecular Formula	C16H21NO3
Molecular Weight	275.34 g/mol
Synonyms	Ethyl (2S)-4-oxo-1-[(1R)-1-phenylethyl]piperidine-2-carboxylate; (2S)-1-[(1R)-1-Phenylethyl]-4-oxopiperidine-2-carboxylic Acid Ethyl Ester; (S)-Ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate; 357154-19-9; 1-[(1R)-1-Phenylethyl]-4-oxo-2-piperidinecarboxylic Acid Ethyl Ester, (2S)-; Chiral Piperidone Ester; (R,S)-Phenylethyl Piperidone Carboxylate Derivative
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 4-Oxo-1-((R)-1-Phenylethyl)Piperidine-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data, including HPLC for purity and chiral assay, to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.