Description

4-Benzyloxyphenylisocyanide is a versatile aromatic isocyanide building block of significant interest in synthetic organic and medicinal chemistry. Its core value lies in its reactivity as a key precursor for multicomponent reactions, enabling the efficient synthesis of complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing new drug candidates and functional molecules. Its defined structure, referenced by CAS NO 356533-74-9, ensures consistent performance in advanced chemical synthesis.

Application

• Key intermediate in multicomponent reactions (MCRs) such as the Ugi and Passerini reactions for library synthesis.
• Building block for the preparation of heterocyclic compounds, including imidazoles, oxazoles, and related pharmacophores.
• Precursor in the synthesis of metal-organic frameworks (MOFs) and coordination polymers for material science applications.
• Research chemical for developing novel catalysts and ligands in transition metal catalysis.
• Intermediate in the discovery and development of new pharmaceutical active ingredients and agrochemicals.
• Starting material for the synthesis of functionalized dyes and pigments.
• Used in peptidomimetic and combinatorial chemistry for drug discovery programs.

Basic Information

Product Name	4-Benzyloxyphenylisocyanide
CAS No.	356533-74-9
Molecular Formula	C14H11NO
Molecular Weight	209.24 g/mol
Synonyms	4-(Benzyloxy)phenyl isocyanide; p-Benzyloxyphenyl isocyanide; 1-Isocyano-4-(phenylmethoxy)benzene; 4-(Phenylmethoxy)phenyl isocyanide; 4-Benzyloxybenzenisocyanid; 4-Benzyloxy-phenylisocyanid; (4-(Benzyloxy)phenyl)isocyanide; Benzyl 4-isocyanophenyl ether
EINECS	Contact for details

Quality Control

Our 4-Benzyloxyphenylisocyanide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.