Description

4-(Trifluoromethyl)Pyridine-2,6-Diol is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl-substituted diol structure offers significant value in modulating the physicochemical properties of target molecules, particularly enhancing metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group improves biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of fluorinated polymers and advanced electronic materials for enhanced performance.
• Chemical Research: A versatile reagent for introducing the trifluoromethylpyridine moiety into complex molecular architectures in medicinal and process chemistry.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-2,6-Diol
CAS No.	356518-28-0
Molecular Formula	C6H4F3NO2
Molecular Weight	179.10 g/mol
Synonyms	2,6-Dihydroxy-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2,6-pyridinediol; 2,6-Pyridinediol, 4-(trifluoromethyl)-; 4-Trifluoromethylpyridine-2,6-diol; 2,6-Dihydroxy-4-trifluoromethylpyridine; 4-(Trifluoromethyl)-2,6-dihydroxypyridine; 4-TFM-2,6-pyridinediol
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-2,6-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. The material is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.