Description

(S)-Di-tert-Butyl 2-Hydroxysuccinate CAS NO 355126-91-9 is a high-purity chiral building block and protected derivative of malic acid, essential for the synthesis of complex pharmaceutical intermediates and fine chemicals. Its value lies in providing a stereochemically defined scaffold that enables the controlled introduction of functional groups while protecting sensitive hydroxyl and carboxyl moieties during multi-step synthetic sequences. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing active pharmaceutical ingredients (APIs), ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic diseases.
• Asymmetric Catalyst Ligand Precursor: Used to synthesize chiral ligands for transition metal catalysts employed in enantioselective hydrogenation and cross-coupling reactions.
• Fine Chemical Synthesis: Serves as a protected form of (S)-malic acid for the controlled preparation of flavor and fragrance compounds, as well as other specialty chemicals requiring specific stereochemistry.
• Agrochemical Research: Employed in the development of chiral herbicides, fungicides, and plant growth regulators where stereochemistry impacts biological activity.
• Polymer Modification: Acts as a monomer or co-monomer for introducing chiral centers and functional groups into specialty polymers, potentially influencing material properties like biodegradability.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic synthesis and for scaling up chiral synthetic routes in process chemistry.

Basic Information

Product Name	(S)-Di-tert-Butyl 2-Hydroxysuccinate
CAS No.	355126-91-9
Molecular Formula	C12H22O5
Molecular Weight	246.30 g/mol
Synonyms	(S)-2-Hydroxysuccinic Acid Di-tert-Butyl Ester; (S)-Di-tert-Butyl Malate; (S)-Malic Acid Di-tert-Butyl Ester; Di-tert-Butyl (S)-(-)-Malate; (2S)-2-Hydroxybutanedioic Acid Di-tert-Butyl Ester; (S)-(-)-Di-tert-Butyl Malate; L-Malic Acid Di-tert-Butyl Ester; DBMB (Di-tert-Butyl Malate BOC)
EINECS	Contact for details

Quality Control

Our (S)-Di-tert-Butyl 2-Hydroxysuccinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, consistent with standards for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.