Description

Azido-Peg6-Ms is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a mesylate leaving group, enabling orthogonal conjugation strategies in bioconjugation and materials science. This compound is essential for creating stable, well-defined molecular architectures, particularly through copper-free click chemistry with alkynes. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material synthesis, where precise and efficient cross-linking is required.

Application

• Bioconjugation and ADC Development: Used to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides via its reactive azide and mesylate termini.
• PEGylation and Linker Chemistry: Serves as a hydrophilic spacer to improve solubility, reduce immunogenicity, and prolong circulation time of therapeutic biomolecules.
• Materials Surface Functionalization: Enables the grafting of functional molecules onto nanoparticles, biosensors, or other material surfaces to introduce specific chemical or biological properties.
• Polymer and Dendrimer Synthesis: Acts as a building block for constructing complex polymeric networks and dendrimers through stepwise click chemistry reactions.
• Chemical Probe Synthesis: Facilitates the creation of activity-based probes for studying enzyme function, protein interactions, and cellular processes.
• Diagnostic Reagent Preparation: Employed in the development of diagnostic assays and imaging agents that require stable, site-specific labeling.

Basic Information

Product Name	Azido-Peg6-Ms
CAS No.	352439-38-4
Molecular Formula	C19H37N3O9S
Molecular Weight	483.58 g/mol
Synonyms	1-Azido-3,6,9,12,15,18-hexaoxahenicosan-21-yl methanesulfonate; Azido-PEG6-mesylate; α-Azido-ω-mesylate hexaethylene glycol; N3-PEG6-OMs; Azido-PEG6-OMs; PEG6 azide mesylate; 21-Azido-3,6,9,12,15,18-hexaoxahenicosyl methanesulfonate; MS-PEG6-N3
EINECS	Contact for details

Quality Control

Our Azido-Peg6-Ms is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.