Description

α-Azido-ω-Hydroxy Octa(Ethylene Glycol) is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group at one terminus and a hydroxyl group at the other. This compound is a critical building block in click chemistry, particularly for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling the efficient and selective conjugation of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in pharmaceuticals, bioconjugation, and advanced materials science who require precise, high-purity linkers for creating functionalized PEGylated constructs, drug delivery systems, and hydrogel networks.

Application

• Bioconjugation and PEGylation: Used as a linker to attach drugs, proteins, peptides, or fluorescent dyes to nanoparticles, surfaces, or other biomolecules via its reactive azide group.
• Click Chemistry Synthesis: Serves as a key reagent in CuAAC reactions to create dendrimers, polymers, and complex macromolecular architectures with controlled functionality.
• Hydrogel and Biomaterial Fabrication: Employed in the cross-linking and functionalization of hydrogels for tissue engineering, 3D cell culture, and controlled release applications.
• Surface Modification: Used to create functional, non-fouling PEG brushes on gold, silicon, or polymer surfaces for biosensors and diagnostic devices.
• ADC (Antibody-Drug Conjugate) Development: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies, improving therapeutic index and stability.
• Polymer Chemistry: Acts as a macroinitiator or monomer in the synthesis of block copolymers and functionalized polymeric materials.
• Diagnostic Reagent Preparation: Utilized in the development of assay components and diagnostic probes requiring water-soluble spacers.

Basic Information

Product Name	α-Azido-ω-Hydroxy Octa(Ethylene Glycol)
CAS No.	352439-36-2
Molecular Formula	C16H33N3O9
Molecular Weight	411.45 g/mol
Synonyms	Azido-PEG8-OH; N3-PEG8-OH; 8-Azido-3,6,9,12,15,18,21-heptaoxatetratriacontan-1-ol; α-Azido-ω-hydroxy PEG8; PEG8-Azide-OH; Heterobifunctional PEG Azide Hydroxy; Azido Octaethylene Glycol; Azido-PEG7-CH2CH2OH
EINECS	Contact for details

Quality Control

Our α-Azido-ω-Hydroxy Octa(Ethylene Glycol) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H and ¹³C), HPLC for purity and impurity profiling, and FT-IR for functional group verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight (NMR)	400 - 420 g/mol
Functional Group Purity (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.